Comparison of inflammation markers and severity of illness among patients with COVID-19, acute psychiatric disorders and comorbidity

dimer, fibrinogen, and comorbid illness are associated with the course and prognosis of COVID- 19. However, the course of acute severe psychiatric disorders overlapping with COVID-19 infec- tion was not investigated and remained as an unclarified research area. This study aimed to dem- onstrate inflammatory markers and the course of patients suffering from both conditions. Methods: Thirty-eight inpatients with COVID-19 and comorbid acute psychiatric disorders (COVID-19+PD), 31 inpatients with COVID-19, and 38 inpatients with an acute psychiatric disor- der (PD) were included in the study. Neutrophil, lymphocyte counts, serum ferritin, lactate dehydrogenase (LDH), D-dimer, fibrinogen, Systemic immune-inflammation index (SII), neutro- phil/lymphocyte ratio (NLR), and C-reactive protein (CRP) were compared to evaluate inflamma- tion levels. Results: Patients with SARS-CoV-2 infection had older age compared to the PD group. CALL (Comorbidity, age, lymphocyte, lactate dehydrogenase) scores which predict the progression risk in patients with COVID-19 pneumonia, of both COVID-19 groups were found similar. The COVID-19+PD had higher SII in the study sample. Additionally, the COVID-19+PD group had higher NLR, ferritin, and CRP levels than those of the PD group. Conclusions: The prognosis of COVID-19 is not worse when accompanied by a psychiatric disor- der. Laboratory assessment can guide clinicians to distinguish those infected with SARS-CoV-2 within psychiatric inpatient units. The biochemical assessment did not robustly support higher